Saroglitazar
(2S)-2-ethoxy-3-[4-[2-[2-methyl-5-(4-methylsulfanylphenyl)pyrrol-1-yl]ethoxy]phenyl]propanoic acid
Molecular Identity
Saroglitazar
(2S)-2-ethoxy-3-[4-[2-[2-methyl-5-(4-methylsulfanylphenyl)pyrrol-1-yl]ethoxy]phenyl]propanoic acid
PubChem CID: 60151560
Saroglitazar is a monocarboxylic acid that is (2S)-2-ethoxy-3-(p-ethoxyphenyl)propanoic acid in which one of the methyl hydrogens of the p-ethoxy substituent has been replaced by the nitrogen of 2-methyl-5-[4-(methylthio)phenyl]-1H-pyrrole. An agonist at the subtypes alpha and gamma of the peroxisome proliferator-activated receptor (PPAR) with predominant PPARalpha activity, it is used in the treatment of type 2 diabetes. It has a role as a hypoglycemic agent, a PPARalpha agonist and a PPARgamma agonist. It is a monocarboxylic acid, a member of pyrroles, an aromatic ether and a methyl sulfide.
2D Structure
Properties
C25H29NO4S
Molecular Formula
439.60
Molecular Weight
g/mol
439.1817
Exact Mass
Da
4.9
XLogP
Drug-like (Lipinski: < 5)
86
TPSA
Good oral absorption (< 140 A²)
1
H-Bond Donors
5
H-Bond Acceptors
532
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
Saroglitazar495399-09-2LipaglynsaroglitazarumE0YMX3S4JDCHEBI:134708DTXSID10197819(2S)-2-ethoxy-3-[4-(2-{2-methyl-5-[4-(methylsulfanyl)phenyl]-1H-pyrrol-1-yl}ethoxy)phenyl]propanoic acid(2S)-2-ethoxy-3-(4-(2-(2-methyl-5-(4-(methylsulfanyl)phenyl)-1H-pyrrol-1-yl)ethoxy)phenyl)propanoic acidRefChem:181452DTXCID20120310(2S)-2-ethoxy-3-(4-(2-(2-methyl-5-(4-(methylsulfanyl)phenyl)-1H-pyrrol-1-yl(ethoxy)phenyl)propanoic acid(S)-2-Ethoxy-3-(4-(2-(2-methyl-5-(4-(methylthio)phenyl)-1H-pyrrol-1-yl)ethoxy)phenyl)propanoic acidSaroglitazar [INN](2S)-2-ethoxy-3-[4-[2-[2-methyl-5-(4-methylsulfanylphenyl)pyrrol-1-yl]ethoxy]phenyl]propanoic acid
Data from PubChem (NCBI)
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