Satavaptan
N-tert-butyl-4-[5'-ethoxy-4-(2-morpholin-4-ylethoxy)-2'-oxospiro[cyclohexane-1,3'-indole]-1'-yl]sulfonyl-3-methoxybenzamide
Molecular Identity
Satavaptan
N-tert-butyl-4-[5'-ethoxy-4-(2-morpholin-4-ylethoxy)-2'-oxospiro[cyclohexane-1,3'-indole]-1'-yl]sulfonyl-3-methoxybenzamide
PubChem CID: 158348
Satavaptan is a vasopressin V2 receptor antagonist that has been shown to improve hyponatremia in patients with cirrhosis, congestive heart failure, and syndrome of inappropriate antidiuresis. It has a role as an aquaretic and a vasopressin receptor antagonist. It is a secondary carboxamide, a member of benzamides, a monomethoxybenzene, a sulfonamide, an aromatic ether, an oxaspiro compound and a member of morpholines.
2D Structure
Properties
C33H45N3O8S
Molecular Formula
643.80
Molecular Weight
g/mol
643.2927
Exact Mass
Da
3.3
XLogP
Drug-like (Lipinski: < 5)
132
TPSA
Good oral absorption (< 140 A²)
1
H-Bond Donors
9
H-Bond Acceptors
1120
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
Satavaptan185913-78-4Satavaptan [INN]AquildaSR-121463SR121463AN-tert-butyl-4-[5'-ethoxy-4-(2-morpholin-4-ylethoxy)-2'-oxospiro[cyclohexane-1,3'-indole]-1'-yl]sulfonyl-3-methoxybenzamideAJS8S3P31HSR121463SR 121463CHEMBL4283439SR-121463BSR-121463A1-(4-(N-tert-butylcarbamoyl)-2-methoxybenzenesulfonyl)-5-ethoxy-3-spiro(4-(2-morpholinoethoxy)cyclohexane)indoline-2-one, phosphate monohydrate cis-isomerBenzamide, N-(1,1-dimethylethyl)-4-((5'-ethoxy-4-(2-(4-morpholinyl)ethoxy)-2'-oxospiro(cyclohexane-1,3'-(3H)indol)-1'(2'H)-yl)sulfonyl)-3-methoxy-, cis-
Data from PubChem (NCBI)
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