Siremadlin
(4S)-5-(5-chloro-1-methyl-2-oxo-3-pyridinyl)-4-(4-chlorophenyl)-2-(2,4-dimethoxypyrimidin-5-yl)-3-propan-2-yl-4H-pyrrolo[3,4-d]imidazol-6-one
Molecular Identity
Siremadlin
(4S)-5-(5-chloro-1-methyl-2-oxo-3-pyridinyl)-4-(4-chlorophenyl)-2-(2,4-dimethoxypyrimidin-5-yl)-3-propan-2-yl-4H-pyrrolo[3,4-d]imidazol-6-one
PubChem CID: 71678098
2D Structure
Properties
C26H24Cl2N6O4
Molecular Formula
555.40
Molecular Weight
g/mol
554.1236
Exact Mass
Da
3.6
XLogP
Drug-like (Lipinski: < 5)
103
TPSA
Good oral absorption (< 140 A²)
0
H-Bond Donors
7
H-Bond Acceptors
987
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
Siremadlin1448867-41-1HDM-201NVP-HDM 201HDM201siremadlinasiremadlinePyrrolo[3,4-d]imidazol-4(1H)-one, 5-(5-chloro-1,2-dihydro-1-methyl-2-oxo-3-pyridinyl)-6-(4-chlorophenyl)-2-(2,4-dimethoxy-5-pyrimidinyl)-5,6-dihydro-1-(1-methylethyl)-, (6S)-0282IF4JC8Hdm 201Pyrrolo(3,4-d)imidazol-4(1H)-one, 5-(5-chloro-1,2-dihydro-1-methyl-2-oxo-3-pyridinyl)-6-(4-chlorophenyl)-2-(2,4-dimethoxy-5-pyrimidinyl)-5,6-dihydro-1-(1-methylethyl)-, (6S)-siremadlinumRefChem:183233NVP-HDM201Siremadlin [USAN]
Data from PubChem (NCBI)
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