TAS-116
3-ethyl-4-[4-[4-(1-methylpyrazol-4-yl)imidazol-1-yl]-3-propan-2-ylpyrazolo[3,4-b]pyridin-1-yl]benzamide
Molecular Identity
TAS-116
3-ethyl-4-[4-[4-(1-methylpyrazol-4-yl)imidazol-1-yl]-3-propan-2-ylpyrazolo[3,4-b]pyridin-1-yl]benzamide
PubChem CID: 67501411
Tas-116 is pimitespib is a specific inhibitor of heat shock protein 90 (Hsp90) subtypes alpha and beta, with potential antineoplastic and chemo/radiosensitizing activities. Upon oral administration, pimitespib specifically binds to and inhibits the activity of Hsp90 alpha and beta; this results in the proteasomal degradation of oncogenic client proteins, which inhibits client protein dependent-signaling, induces apoptosis, and inhibits the proliferation of cells overexpressing HSP90alpha/beta.
2D Structure
Properties
C25H26N8O
Molecular Formula
454.50
Molecular Weight
g/mol
454.2230
Exact Mass
Da
3.1
XLogP
Drug-like (Lipinski: < 5)
109
TPSA
Good oral absorption (< 140 A²)
1
H-Bond Donors
5
H-Bond Acceptors
721
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
TAS-1161260533-36-5PimitespibBenzamide, 3-ethyl-4-[3-(1-methylethyl)-4-[4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl]-1H-pyrazolo[3,4-b]pyridin-1-yl]-PLO044MUDZTAS1163-ethyl-4-[4-[4-(1-methylpyrazol-4-yl)imidazol-1-yl]-3-propan-2-ylpyrazolo[3,4-b]pyridin-1-yl]benzamide3-Ethyl-4-(3-(1-methylethyl)-4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-1H-pyrazolo(3,4-b)pyridin-1-yl)benzamideBenzamide, 3-ethyl-4-(3-(1-methylethyl)-4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-1H-pyrazolo(3,4-b)pyridin-1-yl)-3-ethyl-4-(4-(4-(1-methylpyrazol-4-yl)imidazol-1-yl)-3-propan-2-ylpyrazolo(3,4-b)pyridin-1-yl)benzamideRefChem:187472HSP90alpha/beta Inhibitor TAS-116Heat Shock Protein 90 alpha/beta Inhibitor TAS-1163-ethyl-4-(4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-3-(propan-2-yl)-1H-pyrazolo(3,4-b)pyridin-1-yl)benzamideJeselhy
Data from PubChem (NCBI)
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