Protirelin
(2S)-N-[(2S)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
Molecular Identity
Protirelin
(2S)-N-[(2S)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
PubChem CID: 638678
Protirelin is a tripeptide composed of L-pyroglutamyl, L-histidyl and L-prolinamide residues joined in sequence. It has a role as a human metabolite. It is a peptide hormone and a tripeptide.
2D Structure
Properties
C16H22N6O4
Molecular Formula
362.38
Molecular Weight
g/mol
362.1703
Exact Mass
Da
-2.5
XLogP
Drug-like (Lipinski: < 5)
150
TPSA
May have limited oral absorption
4
H-Bond Donors
5
H-Bond Acceptors
597
Complexity
SMILES
Canonical SMILES
SMILES: C1CC(N(C1)C(=O)C(CC2=CN=CN2)NC(=O)C3CCC(=O)N3)C(=O)NIsomeric SMILES
SMILES: C1C[C@H](N(C1)C(=O)[C@H](CC2=CN=CN2)NC(=O)[C@@H]3CCC(=O)N3)C(=O)NSynonyms(20)
protirelin24305-27-9ThyroliberinLopremoneSynthetic TRHRifathyroinThypinoneThyrotropin-releasing factorTSH-releasing factorProtirelineThyrotropic-releasing factor5-Oxo-L-prolyl-L-histidyl-L-prolinamideABBOTT-38579ProtirelinumTHYREL TRH
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to Protirelin
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