Osimertinib mesylate
N-[2-[2-(dimethylamino)ethyl-methylamino]-4-methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]phenyl]prop-2-enamide;methanesulfonic acid
Molecular Identity
Osimertinib mesylate
N-[2-[2-(dimethylamino)ethyl-methylamino]-4-methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]phenyl]prop-2-enamide;methanesulfonic acid
PubChem CID: 78357807
Osimertinib mesylate is a methanesulfonate (mesylate) salt prepared from equimolar amounts of osimertinib and methanesulfonic acid. It is used for treatment of EGFR T790M mutation positive non-small cell lung cancer. It has a role as an antineoplastic agent and an epidermal growth factor receptor antagonist. It contains an osimertinib(1+).
2D Structure
Properties
C29H37N7O5S
Molecular Formula
595.70
Molecular Weight
g/mol
595.2577
Exact Mass
Da
150
TPSA
May have limited oral absorption
3
H-Bond Donors
10
H-Bond Acceptors
845
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
Osimertinib mesylate1421373-66-1AZD-9291 mesylateAZD9291 mesylateMereletinib mesylateosimertinib mesilateMereletinib mesilateRDL94R2A162-Propenamide, N-(2-((2-(dimethylamino)ethyl)methylamino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl)amino)phenyl)-, methanesulfonate (1:1)CHEBI:90948DTXSID101027822N-(2-((2-(dimethylamino)ethyl)methylamino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl)amino)phenyl)-2-propenamide methanesulfonate (1:1)N-[2-[[2-(Dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide methanesulfonate (1:1)RefChem:58258DTXCID601513393
Data from PubChem (NCBI)
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