Telatinib
4-[[4-(4-chloroanilino)furo[2,3-d]pyridazin-7-yl]oxymethyl]-N-methylpyridine-2-carboxamide
Molecular Identity
Telatinib
4-[[4-(4-chloroanilino)furo[2,3-d]pyridazin-7-yl]oxymethyl]-N-methylpyridine-2-carboxamide
PubChem CID: 9808844
Telatinib is a member of the class of furopyridazines that is furo[2,3-d]pyridazine substituted by (4-chlorophenyl)amino and [2-(methylcarbamoyl)pyridin-4-yl]methoxy groups at positions 4 and 7, respectively. It is a potent inhibitor of VEGFR2/3, c-Kit and PDGFRalpha. It has a role as an antineoplastic agent, an angiogenesis inhibitor, an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor, a vascular endothelial growth factor receptor antagonist and an apoptosis inducer. It is a member of anilines, a furopyridazine, a pyridinecarboxamide, an aromatic ether and a member of monochlorobenzenes.
2D Structure
Properties
C20H16ClN5O3
Molecular Formula
409.80
Molecular Weight
g/mol
409.0942
Exact Mass
Da
3.1
XLogP
Drug-like (Lipinski: < 5)
102
TPSA
Good oral absorption (< 140 A²)
2
H-Bond Donors
7
H-Bond Acceptors
548
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
Telatinib332012-40-5Bay 57-9352BAY-579352telatinibumBAY-57-93524-[[4-(4-chloroanilino)furo[2,3-d]pyridazin-7-yl]oxymethyl]-N-methylpyridine-2-carboxamide18P7197Q7J4-(((4-((4-CHLOROPHENYL)AMINO)FURO(2,3-D)PYRIDAZIN-7-YL)OXY)METHYL)-N-METHYLPYRIDINE-2-CARBOXAMIDE4-((4-(4-chloroanilino)furo(2,3-d)pyridazin-7-yl)oxymethyl)-N-methylpyridine-2-carboxamideRefChem:187740Telatinib [INN]MFCD182514534-[[4-(4-Chloroanilino)furo[2,3-d]pyridazin-7-yl]oxymethyl]-N-methyl-pyridine-2-carboxamideTelatinib(BAY 57-9352)
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to Telatinib
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