Tenofovir
[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethylphosphonic acid
Molecular Identity
Tenofovir
[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethylphosphonic acid
PubChem CID: 464205
Tenofovir (anhydrous) is a member of the class of phosphonic acids that is methylphosphonic acid in which one of the methyl hydrogens is replaced by a [(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy group. An inhibitor of HIV-1 reverse transcriptase, the bis(isopropyloxycarbonyloxymethyl) ester (disoproxil ester) prodrug is used as the fumaric acid salt in combination therapy for the treatment of HIV infection. It has a role as an antiviral drug, a drug metabolite and a HIV-1 reverse transcriptase inhibitor. It is a member of phosphonic acids and a nucleoside analogue. It is a conjugate acid of a tenofovir(1-).
2D Structure
Properties
C9H14N5O4P
Molecular Formula
287.21
Molecular Weight
g/mol
287.0783
Exact Mass
Da
-1.6
XLogP
Drug-like (Lipinski: < 5)
136
TPSA
Good oral absorption (< 140 A²)
3
H-Bond Donors
8
H-Bond Acceptors
354
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
Tenofovir147127-20-6PMPA(R)-9-(2-Phosphonomethoxypropyl)adenine(R)-PMPAtenofovir (anhydrous)Tenofovir anhydrousGS-1275anhydrous tenofovirtenofovir (anh.)GS-1278({[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methyl)phosphonic acidW4HFE001U5CHEBI:63625(R)-9-(Phosphonomethoxypropyl)adenine
Data from PubChem (NCBI)
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