Tideglusib
4-benzyl-2-naphthalen-1-yl-1,2,4-thiadiazolidine-3,5-dione
Molecular Identity
Tideglusib
4-benzyl-2-naphthalen-1-yl-1,2,4-thiadiazolidine-3,5-dione
PubChem CID: 11313622
Tideglusib is a member of the class of thiadiazolidines that is 1,2,4-thiadiazolidine-3,5-dione which is substituted by a naphthalen-1-yl group at position 2 and by a benzyl group at position 4. It is a non-ATP competitive inhibitor of glycogen synthase kinase 3beta (GSK3beta) and has neuroprotective effects. Currently under clinical investigation for the treatment of Alzheimer's disease and progressive supranuclear palsy. It has a role as a neuroprotective agent, an anti-inflammatory agent, an apoptosis inducer and an EC 2.7.11.26 (tau-protein kinase) inhibitor. It is a member of benzenes, a member of naphthalenes and a thiadiazolidine.
2D Structure
Properties
C19H14N2O2S
Molecular Formula
334.40
Molecular Weight
g/mol
334.0776
Exact Mass
Da
4.3
XLogP
Drug-like (Lipinski: < 5)
65.9
TPSA
Good oral absorption (< 140 A²)
0
H-Bond Donors
3
H-Bond Acceptors
492
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
Tideglusib865854-05-3NP-12NP0311124-Benzyl-2-(naphthalen-1-yl)-1,2,4-thiadiazolidine-3,5-dioneNP-031112tideglusibumZentylorNyptaQ747Y6TT42CHEBI:147398DTXSID902356824-benzyl-2-(a-naphtyl)-1,2,4-thiadiazolidine-3,5-dioneNP12 compoundNP-12 compound
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to Tideglusib
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