Molecular Identity
Tizanidine
5-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine
PubChem CID: 5487
Tizanidine is 2,1,3-Benzothiadiazole substituted at C-4 by a 1-imidazolin-2-ylamino group and at C-4 by a chloro group. It is an agonist at alpha2-adrenergic receptor sites. It has a role as an alpha-adrenergic agonist and a muscle relaxant. It is a member of imidazoles and a benzothiadiazole.
2D Structure
Properties
C9H8ClN5S
Molecular Formula
253.71
Molecular Weight
g/mol
253.0189
Exact Mass
Da
1.1
XLogP
Drug-like (Lipinski: < 5)
90.4
TPSA
Good oral absorption (< 140 A²)
2
H-Bond Donors
4
H-Bond Acceptors
300
Complexity
SMILES
Canonical SMILES
SMILES: C1CN=C(N1)NC2=C(C=CC3=NSN=C32)ClIsomeric SMILES
SMILES: C1CN=C(N1)NC2=C(C=CC3=NSN=C32)ClSynonyms(20)
tizanidine51322-75-9SirdaludTizanidinaTizanidinum5-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine5-Chloro-4-(2-imidazolin-2-ylamino)-2,1,3-benzothiadiazoleDTXSID90236796AI06C00GWDTXCID203679CHEBI:636292,1,3-Benzothiadiazol-4-amine, 5-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-RefChem:585655-chloro-4-(2-imidazolin-2-yl-amino)-2,1,3-benzothiadiazoleM03BX02
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to Tizanidine
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