Trichostatin A
(2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide
Molecular Identity
Trichostatin A
(2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide
PubChem CID: 444732
Trichostatin A is a hydroxamic acid, a trichostatin and an antibiotic antifungal agent. It has a role as a geroprotector, an EC 3.5.1.98 (histone deacetylase) inhibitor and a bacterial metabolite. It is functionally related to a (R)-trichostatic acid.
2D Structure
Properties
C17H22N2O3
Molecular Formula
302.37
Molecular Weight
g/mol
302.1630
Exact Mass
Da
2.7
XLogP
Drug-like (Lipinski: < 5)
69.6
TPSA
Good oral absorption (< 140 A²)
2
H-Bond Donors
4
H-Bond Acceptors
447
Complexity
SMILES
Canonical SMILES
SMILES: CC(C=C(C)C=CC(=O)NO)C(=O)C1=CC=C(C=C1)N(C)CIsomeric SMILES
SMILES: C[C@H](/C=C(\C)/C=C/C(=O)NO)C(=O)C1=CC=C(C=C1)N(C)CSynonyms(20)
trichostatin A58880-19-6DTXSID6037063CHEBI:460243X2S926L3Z2,4-Heptadienamide, 7-(4-(dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-7-(4-(Dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamideVTR297VTR-297(2E,4E,6R)-7-(4-(dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamideNSC-311042TSA antibioitc7-[4-(DIMETHYLAMINO)PHENYL]-N-HYDROXY-4,6-DIMETHYL-7-OXO-2,4-HEPTADIENAMIDENSC311042RefChem:899268
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to Trichostatin A
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