Molecular Identity
Trifluridine
1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-(trifluoromethyl)pyrimidine-2,4-dione
PubChem CID: 6256
Trifluridine is a pyrimidine 2'-deoxyribonucleoside compound having 5-trifluoromethyluracil as the nucleobase. An antiviral drug used mainly in the treatment of primary keratoconjunctivitis and recurrent epithelial keratitis. It has a role as an antimetabolite, an antineoplastic agent, an antiviral drug and an EC 2.1.1.45 (thymidylate synthase) inhibitor. It is a pyrimidine 2'-deoxyribonucleoside, an organofluorine compound and a nucleoside analogue.
2D Structure
Properties
C10H11F3N2O5
Molecular Formula
296.20
Molecular Weight
g/mol
296.0620
Exact Mass
Da
-0.5
XLogP
Drug-like (Lipinski: < 5)
99.1
TPSA
Good oral absorption (< 140 A²)
3
H-Bond Donors
8
H-Bond Acceptors
464
Complexity
SMILES
Canonical SMILES
SMILES: C1C(C(OC1N2C=C(C(=O)NC2=O)C(F)(F)F)CO)OIsomeric SMILES
SMILES: C1[C@@H]([C@H](O[C@H]1N2C=C(C(=O)NC2=O)C(F)(F)F)CO)OSynonyms(20)
TrifluridineTRIFLUOROTHYMIDINE70-00-8ViropticF3DThdTrifluoromethyldeoxyuridineTrifluridinumTrifluridinaF3TDR5-(Trifluoromethyl)deoxyuridineTFDU5-Trifluoromethyl-2-deoxyuridine2'-Deoxy-5-(trifluoromethyl)uridineTrifluorothymine deoxyriboside5-Trifluoromethyl-2'-deoxyuridine
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to Trifluridine
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