TREM2 agonist-2
5-(4-chloro-2-fluorophenyl)-2,3-dimethyl-7-[(2R,4S)-2-(1-methylpyrazol-4-yl)oxan-4-yl]pyrido[3,4-b]pyrazine
Molecular Identity
TREM2 agonist-2
5-(4-chloro-2-fluorophenyl)-2,3-dimethyl-7-[(2R,4S)-2-(1-methylpyrazol-4-yl)oxan-4-yl]pyrido[3,4-b]pyrazine
PubChem CID: 165412595
2D Structure
Properties
C24H23ClFN5O
Molecular Formula
451.90
Molecular Weight
g/mol
451.1575
Exact Mass
Da
3.6
XLogP
Drug-like (Lipinski: < 5)
65.7
TPSA
Good oral absorption (< 140 A²)
0
H-Bond Donors
6
H-Bond Acceptors
646
Complexity
SMILES
Canonical SMILES
SMILES: CC1=NC2=CC(=NC(=C2N=C1C)C3=C(C=C(C=C3)Cl)F)C4CCOC(C4)C5=CN(N=C5)CIsomeric SMILES
SMILES: CC1=NC2=CC(=NC(=C2N=C1C)C3=C(C=C(C=C3)Cl)F)[C@H]4CCO[C@H](C4)C5=CN(N=C5)CSynonyms(19)
TREM2 agonist-22738485-98-62738485-99-7Rel-5-(4-Chloro-2-fluorophenyl)-2,3-dimethyl-7-[(2R,4S)-tetrahydro-2-(1-methyl-1H-pyrazol-4-yl)-2H-pyran-4-yl]pyrido[3,4-b]pyrazine5-(4-Chloro-2-fluorophenyl)-2,3-dimethyl-7-((2R,4S)-2-(1-methyl-1H-pyrazol-4-yl)tetrahydro-2H-pyran-4-yl)pyrido[3,4-b]pyrazine5-(4-chloro-2-fluorophenyl)-2,3-dimethyl-7-[(2R,4S)-2-(1-methylpyrazol-4-yl)oxan-4-yl]pyrido[3,4-b]pyrazineorb1687293orb1819242SCHEMBL24010341SCHEMBL30160568GTPL14242EX-A16970VG3927T62750LVG-3927
Data from PubChem (NCBI)
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