Suzetrigine
4-[[(2R,3S,4S,5R)-3-(3,4-difluoro-2-methoxyphenyl)-4,5-dimethyl-5-(trifluoromethyl)oxolane-2-carbonyl]amino]pyridine-2-carboxamide
Molecular Identity
Suzetrigine
4-[[(2R,3S,4S,5R)-3-(3,4-difluoro-2-methoxyphenyl)-4,5-dimethyl-5-(trifluoromethyl)oxolane-2-carbonyl]amino]pyridine-2-carboxamide
PubChem CID: 156445116
Suzetrigine is a member of the class of oxolanes that is oxolane substituted by 4-aminoacyl-pyridine-2-carboxamide, 3,4-difluoro-2-methoxyphenyl, methyl, and trifluoromethyl groups at positions 2, 3, 4, 5, and 5, respectively (the 2R,3S,4S,5R-stereoisomer). It is a selective blocker of the NaV 1.8 voltage-gated sodium channel and has been approved for the treatment of moderate to severe acute pain in adults. It has a role as a non-narcotic analgesic and a voltage-gated sodium channel blocker. It is a primary carboxamide, a secondary carboxamide, a monomethoxybenzene, a pyridinecarboxamide, a member of oxolanes and a difluorobenzene.
2D Structure
Properties
C21H20F5N3O4
Molecular Formula
473.40
Molecular Weight
g/mol
473.1374
Exact Mass
Da
3
XLogP
Drug-like (Lipinski: < 5)
104
TPSA
Good oral absorption (< 140 A²)
2
H-Bond Donors
10
H-Bond Acceptors
741
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
Suzetrigine2649467-58-1VX-548JOURNAVXVXC-548VRT-1737548LOG73M21H54-[[(2R,3S,4S,5R)-3-(3,4-difluoro-2-methoxyphenyl)-4,5-dimethyl-5-(trifluoromethyl)oxolane-2-carbonyl]amino]pyridine-2-carboxamide4-(((2R,3S,4S,5R)-3-(3,4-difluoro-2-methoxyphenyl)-4,5-dimethyl-5-(trifluoromethyl)oxolane-2-carbonyl)amino)pyridine-2-carboxamideRefChem:1099300SuzetriginaVX5484-((2R,3S,4S,5R)-3-(3,4-Difluoro-2-Methoxyphenyl)-4,5-Dimethyl-5-(Trifluoromethyl)Tetrahydrofuran-2-Carboxamido)Picolinamide4-[(2R,3S,4S,5R)-3-(3,4-Difluoro-2-methoxyphenyl)-4,5-dimethyl-5-(trifluoromethyl)oxolane-2-amido]pyridine-2-carboxamide4-[[[(2R,3S,4S,5R)-3-(3,4-Difluoro-2-methoxyphenyl)tetrahydro-4,5-dimethyl-5-(trifluoromethyl)-2-furanyl]carbonyl]amino]-2-pyridinecarboxamide
Data from PubChem (NCBI)
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