Veliparib
2-[(2R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide
Molecular Identity
Veliparib
2-[(2R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide
PubChem CID: 11960529
Veliparib is a benzimidazole substituted with a carbamoyl group at C-4 and a (2R)-2-methylpyrrolidin-2-yl moiety at C-2. It is a potent, orally bioavailable PARP inhibitor. It has a role as an EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor.
2D Structure
Properties
C13H16N4O
Molecular Formula
244.29
Molecular Weight
g/mol
244.1324
Exact Mass
Da
0.5
XLogP
Drug-like (Lipinski: < 5)
83.8
TPSA
Good oral absorption (< 140 A²)
3
H-Bond Donors
3
H-Bond Acceptors
348
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
Veliparib912444-00-9ABT 888ABT8882-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamidePARP-1 INHIBITOR ABT-88801O4K0631NCHEBI:628802-((r)-2-methylpyrrolidin-2-yl)-1h-benzimidazole-4-carboxamide2-[(R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamideDTXSID90238456NSC7376642-((2R)-2-methylpyrrolidin-2-yl)-1H-benzimidazole-4-carboxamideveliparibumRefChem:901780
Data from PubChem (NCBI)
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