Tenofovir Alafenamide Fumarate
(E)-but-2-enedioic acid;bis(propan-2-yl (2S)-2-[[[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-phenoxyphosphoryl]amino]propanoate)
Molecular Identity
Tenofovir Alafenamide Fumarate
(E)-but-2-enedioic acid;bis(propan-2-yl (2S)-2-[[[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-phenoxyphosphoryl]amino]propanoate)
PubChem CID: 71492247
Tenofovir alafenamide fumarate is a fumarate salt prepared from tenofovir alafenamide by reaction of one molecule of fumaric acid for every two molecules of tenofovir alafenamide. A prodrug for tenofovir, it is used in combination therapy for the treatment of HIV-1 infection. It has a role as an antiviral drug, a prodrug and a HIV-1 reverse transcriptase inhibitor. It contains a tenofovir alafenamide(1+).
2D Structure
Properties
C46H62N12O14P2
Molecular Formula
1069.00
Molecular Weight
g/mol
1068.3984
Exact Mass
Da
362
TPSA
May have limited oral absorption
6
H-Bond Donors
24
H-Bond Acceptors
799
Complexity
SMILES
Canonical SMILES
SMILES: CC(C)OC(=O)C(C)NP(=O)(COC(C)CN1C=NC2=C(N=CN=C21)N)OC3=CC=CC=C3.CC(C)OC(=O)C(C)NP(=O)(COC(C)CN1C=NC2=C(N=CN=C21)N)OC3=CC=CC=C3.C(=CC(=O)O)C(=O)OIsomeric SMILES
SMILES: C[C@H](CN1C=NC2=C(N=CN=C21)N)OC[P@@](=O)(N[C@@H](C)C(=O)OC(C)C)OC3=CC=CC=C3.C[C@H](CN1C=NC2=C(N=CN=C21)N)OC[P@@](=O)(N[C@@H](C)C(=O)OC(C)C)OC3=CC=CC=C3.C(=C/C(=O)O)\C(=O)OSynonyms(20)
Tenofovir Alafenamide fumarate1392275-56-7tenofovir alafenamide hemifumarateGS-7340 HemifumarateGS-7340-03CHEBI:90923FWF6Q91TZOTENOFOVIR ALAFENAMIDE FUMARATE (2:1)TAFDESCOVY COMPONENT TENOFOVIR ALAFENAMIDE FUMARATEODEFSEY COMPONENT TENOFOVIR ALAFENAMIDE FUMARATESYMTUZA COMPONENT TENOFOVIR ALAFENAMIDE FUMARATEBIKTARVY COMPONENT TENOFOVIR ALAFENAMIDE FUMARATETENOFOVIR ALAFENAMIDE FUMARATE COMPONENT OF ODEFSEY1-METHYLETHYL N-((S)-(((1R)-2-(6-AMINO-9H-PURIN-9-YL)-1-METHYLETHOXY)METHYL(PHENOXYPHOSPHINOYL)-L-ALANINATE, (2E)-2-BUTENEDIOATE
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to Tenofovir Alafenamide Fumarate
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