Arv-471
(3S)-3-[6-[4-[[1-[4-[(1R,2S)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalen-1-yl]phenyl]piperidin-4-yl]methyl]piperazin-1-yl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione
Molecular Identity
Arv-471
(3S)-3-[6-[4-[[1-[4-[(1R,2S)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalen-1-yl]phenyl]piperidin-4-yl]methyl]piperazin-1-yl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione
PubChem CID: 134562533
2D Structure
Properties
C45H49N5O4
Molecular Formula
723.90
Molecular Weight
g/mol
723.3785
Exact Mass
Da
6.4
XLogP
Above Lipinski threshold
96.4
TPSA
Good oral absorption (< 140 A²)
2
H-Bond Donors
7
H-Bond Acceptors
1310
Complexity
SMILES
Canonical SMILES
SMILES: C1CC2=C(C=CC(=C2)O)C(C1C3=CC=CC=C3)C4=CC=C(C=C4)N5CCC(CC5)CN6CCN(CC6)C7=CC8=C(C=C7)C(=O)N(C8)C9CCC(=O)NC9=OIsomeric SMILES
SMILES: C1CC2=C(C=CC(=C2)O)[C@H]([C@H]1C3=CC=CC=C3)C4=CC=C(C=C4)N5CCC(CC5)CN6CCN(CC6)C7=CC8=C(C=C7)C(=O)N(C8)[C@H]9CCC(=O)NC9=OSynonyms(20)
ARV-471VepdegestrantARV471ARV-471 (protac)Arv 471PF-07850327PF07850327RefChem:199635PROTAC Protein Degrader ARV-471ER alpha PROTAC Protein Degrader ARV-471PF 07850327Estrogen Receptor alpha PROTAC Protein Degrader ARV-471ER alpha Proteolysis-targeting Chimera Protein Degrader ARV-4712229711-68-4(S)-3-(5-(4-((1-(4-((1R,2S)-6-Hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalen-1-yl)phenyl)piperidin-4-yl)methyl)piperazin-1-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to Arv-471
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