Molecular Identity
Vorinostat
N'-hydroxy-N-phenyloctanediamide
PubChem CID: 5311
Vorinostat is a dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL). It has a role as an antineoplastic agent, an EC 3.5.1.98 (histone deacetylase) inhibitor and an apoptosis inducer. It is a hydroxamic acid and a dicarboxylic acid diamide. It is functionally related to a hydroxylamine, an aniline and a suberic acid.
2D Structure
Properties
C14H20N2O3
Molecular Formula
264.32
Molecular Weight
g/mol
264.1474
Exact Mass
Da
1.9
XLogP
Drug-like (Lipinski: < 5)
78.4
TPSA
Good oral absorption (< 140 A²)
3
H-Bond Donors
3
H-Bond Acceptors
276
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
Vorinostat149647-78-9SAHAsuberoylanilide hydroxamic acidZolinzaN-hydroxy-N'-phenyloctanediamideN1-hydroxy-N8-phenyloctanediamideSuberanilohydroxamic acidMK-0683MK0683Octanediamide, N-hydroxy-N'-phenyl-N'-hydroxy-N-phenyloctanediamideOCTANEDIOIC ACID HYDROXYAMIDE PHENYLAMIDEvorinostatumNSC-701852
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to Vorinostat
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