Molecular Identity
Fluocinolone Acetonide
(1S,2S,4R,8S,9S,11S,12R,13S,19S)-12,19-difluoro-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one
PubChem CID: 6215
Fluocinolone acetonide is a fluorinated steroid that is flunisolide in which the hydrogen at position 9 is replaced by fluorine. A corticosteroid with glucocorticoid activity, it is used (both as the anhydrous form and as the dihydrate) in creams, gels and ointments for the treatment of various skin disorders. It has a role as an anti-inflammatory drug and an antipruritic drug. It is a primary alpha-hydroxy ketone, a glucocorticoid, a 21-hydroxy steroid, an 11beta-hydroxy steroid, a 20-oxo steroid, an organic heteropentacyclic compound, a fluorinated steroid, a cyclic ketal and a 3-oxo-Delta(1),Delta(4)-steroid.
2D Structure
Properties
C24H30F2O6
Molecular Formula
452.50
Molecular Weight
g/mol
452.2010
Exact Mass
Da
2.5
XLogP
Drug-like (Lipinski: < 5)
93.1
TPSA
Good oral absorption (< 140 A²)
2
H-Bond Donors
8
H-Bond Acceptors
960
Complexity
SMILES
Canonical SMILES
SMILES: CC1(OC2CC3C4CC(C5=CC(=O)C=CC5(C4(C(CC3(C2(O1)C(=O)CO)C)O)F)C)F)CIsomeric SMILES
SMILES: C[C@]12C[C@@H]([C@]3([C@H]([C@@H]1C[C@@H]4[C@]2(OC(O4)(C)C)C(=O)CO)C[C@@H](C5=CC(=O)C=C[C@@]53C)F)F)OSynonyms(20)
FLUOCINOLONE ACETONIDE67-73-2SynalarFluonidFlucinarFlupollonSynamolSynandoneJellinCoriphateDermalarFluovitifPercutinaRadiocinRetisert
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to Fluocinolone Acetonide
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