Vandetanib
N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine
Molecular Identity
Vandetanib
N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine
PubChem CID: 3081361
Vandetanib is a quinazoline that is 7-[(1-methylpiperidin-4-yl)methoxy]quinazoline bearing additional methoxy and 4-bromo-2-fluorophenylamino substituents at positions 6 and 4 respectively. Used for the treatment of symptomatic or progressive medullary thyroid cancer in patients with unresectable locally advanced or metastatic disease. It has a role as an antineoplastic agent and a tyrosine kinase inhibitor. It is a member of piperidines, a secondary amine, an aromatic ether, an organobromine compound, an organofluorine compound and a member of quinazolines.
2D Structure
Properties
C22H24BrFN4O2
Molecular Formula
475.40
Molecular Weight
g/mol
474.1067
Exact Mass
Da
4.9
XLogP
Drug-like (Lipinski: < 5)
59.5
TPSA
Good oral absorption (< 140 A²)
1
H-Bond Donors
7
H-Bond Acceptors
539
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
Vandetanib443913-73-3ZactimaZD6474CaprelsaN-(4-Bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amineN-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amineZD-6474ZD 6474GNF-PF-2188ZD-64NSC-744325NSC-760766YO460OQ37KDTXSID1046681
Data from PubChem (NCBI)
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Trials and conditions connected to Vandetanib
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