ZSTK474
4-[4-[2-(difluoromethyl)benzimidazol-1-yl]-6-morpholin-4-yl-1,3,5-triazin-2-yl]morpholine
Molecular Identity
ZSTK474
4-[4-[2-(difluoromethyl)benzimidazol-1-yl]-6-morpholin-4-yl-1,3,5-triazin-2-yl]morpholine
PubChem CID: 11647372
ZSTK-474 is a triamino-1,3,5-triazine that is 1,3,5-triazine in which two of the hydrogens have been replaced by morpholin-4-yl groups while the third hydrogen has been replaced by a 2-(difluoromethyl)benzimidazol-1-yl group. It is an inhibitor of phosphatidylinositol 3-kinase. It has a role as an antineoplastic agent and an EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor. It is a member of benzimidazoles, an organofluorine compound, a triamino-1,3,5-triazine and a member of morpholines.
2D Structure
Properties
C19H21F2N7O2
Molecular Formula
417.40
Molecular Weight
g/mol
417.1725
Exact Mass
Da
2.3
XLogP
Drug-like (Lipinski: < 5)
81.4
TPSA
Good oral absorption (< 140 A²)
0
H-Bond Donors
10
H-Bond Acceptors
539
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
ZSTK474475110-96-4ZSTK-474ZSTK 474TCMDC-1370042-(2-Difluoromethylbenzimidazol-1-yl)-4,6-bis(morpholino)-1,3,5-triazineK0068GK39ACHEBI:90545DTXSID301971792-(difluoromethyl)-1-(4,6-di-4-morpholinyl-1,3,5-triazin-2-yl)-1H-benzimidazole2-(difluoromethyl)-1-(4,6-di(morpholin-4-yl)-1,3,5-triazin-2-yl)benzimidazole2-(difluoromethyl)-1-[4,6-di(morpholin-4-yl)-1,3,5-triazin-2-yl]benzimidazoleRefChem:909420DTXCID901196701-(bis(morpholin-4-yl)-1,3,5-triazin-2-yl)-2-(difluoromethyl)-1H-1,3-benzodiazole
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to ZSTK474
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