Molecular Identity
Aldosterone
(8S,9S,10R,11S,13R,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10-methyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthrene-13-carbaldehyde
PubChem CID: 5839
Aldosterone is a pregnane-based steroidal hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland, and acts on the distal tubules and collecting ducts of the kidney to cause the conservation of sodium, secretion of potassium, increased water retention, and increased blood pressure. The overall effect of aldosterone is to increase reabsorption of ions and water in the kidney. It has a role as a mouse metabolite and a human metabolite. It is a steroid aldehyde, a primary alpha-hydroxy ketone, a mineralocorticoid, a 21-hydroxy steroid, an 11beta-hydroxy steroid, a 20-oxo steroid, a 18-oxo steroid, a 3-oxo-Delta(4) steroid and a C21-steroid hormone. It derives from a hydride of a pregnane.
2D Structure
Properties
C21H28O5
Molecular Formula
360.40
Molecular Weight
g/mol
360.1937
Exact Mass
Da
1.1
XLogP
Drug-like (Lipinski: < 5)
91.7
TPSA
Good oral absorption (< 140 A²)
2
H-Bond Donors
5
H-Bond Acceptors
682
Complexity
SMILES
Canonical SMILES
SMILES: CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4C(=O)CO)C=O)OIsomeric SMILES
SMILES: C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@H]4C(=O)CO)C=O)OSynonyms(20)
ALDOSTERONE52-39-1(+)-AldosteroneAldosteronaAldosteronum11beta,21-Dihydroxy-3,20-diketo-4-pregnen-18-al11beta,21-Dihydroxypregn-4-ene-3,18,20-trione(11BETA)-11,21-DIHYDROXY-3,20-DIOXOPREGN-4-EN-18-AL11beta,21-dihydroxy-3,20-dioxopregn-4-en-18-al(8S,9S,10R,11S,13R,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10-methyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthrene-13-carbaldehydeNSC-7385611beta,21-Dihydroxy-3,20-dioxo-4-pregnen-18-al11beta,21-dihydroxy-3,20-dioxo-pregn-4-ene-18-al4964P6T9RBDTXSID7022419
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to Aldosterone
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