Molecular Identity
Betahistine
N-methyl-2-pyridin-2-ylethanamine
PubChem CID: 2366
Betahistine is an aminoalkylpyridine that is pyridine substituted by a 2-(methylamino)ethyl group at position 2. It acts as a histamine agonist and a vasodilator, and is thought to improve the microcirculation of the labyrinth, resulting in reduced endolymphatic pressure. It is used (generally as the hydrochloride or mesylate salt) to reduce the symptoms of vertigo, tinnitus, and hearing loss associated with Mnire's disease. It has a role as a vasodilator agent and a H1-receptor agonist. It is an aminoalkylpyridine and a secondary amino compound.
2D Structure
Properties
C8H12N2
Molecular Formula
136.19
Molecular Weight
g/mol
136.1000
Exact Mass
Da
0.4
XLogP
Drug-like (Lipinski: < 5)
24.9
TPSA
Good oral absorption (< 140 A²)
1
H-Bond Donors
2
H-Bond Acceptors
83
Complexity
SMILES
Canonical SMILES
SMILES: CNCCC1=CC=CC=N1Isomeric SMILES
SMILES: CNCCC1=CC=CC=N1Synonyms(20)
betahistine5638-76-6N-Methyl-2-pyridineethanamineVasomotal2-Pyridineethanamine, N-methyl-Betahistina2-[2-(Methylamino)ethyl]pyridineN-methyl-2-pyridin-2-ylethanamineBetahistinummethyl[2-(pyridin-2-yl)ethyl]amineBetaistina2-(2-(Methylamino)ethyl)pyridineVestibo(2-(2-Pyridyl)ethyl)methylamine[2-(2-Pyridyl)ethyl]methylamine
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to Betahistine
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