Molecular Identity
Chlorpropamide
1-(4-chlorophenyl)sulfonyl-3-propylurea
PubChem CID: 2727
Chlorpropamide is an N-sulfonylurea that is urea in which a hydrogen attached to one of the nitrogens is substituted by 4-chlorobenzenesulfonyl group and a hydrogen attached to the other nitrogen is substituted by propyl group. Chlorpropamide is a hypoglycaemic agent used in the treatment of type 2 (non-insulin-dependent) diabetes mellitus not responding to dietary modification. It has a role as a hypoglycemic agent and an insulin secretagogue. It is a N-sulfonylurea and a member of monochlorobenzenes.
2D Structure
Properties
C10H13ClN2O3S
Molecular Formula
276.74
Molecular Weight
g/mol
276.0335
Exact Mass
Da
2.3
XLogP
Drug-like (Lipinski: < 5)
83.7
TPSA
Good oral absorption (< 140 A²)
2
H-Bond Donors
3
H-Bond Acceptors
345
Complexity
SMILES
Canonical SMILES
SMILES: CCCNC(=O)NS(=O)(=O)C1=CC=C(C=C1)ClIsomeric SMILES
SMILES: CCCNC(=O)NS(=O)(=O)C1=CC=C(C=C1)ClSynonyms(20)
chlorpropamide94-20-2DiabineseGlucamideDiabeneseMelitase4-chloro-N-(propylcarbamoyl)benzenesulfonamideClorpropamidaClorpropamideClorpropamidProdiabenChlorpropamidum1-(p-Chlorobenzenesulfonyl)-3-propylurea1-Propyl-3-(p-chlorobenzenesulfonyl)ureaN-(4-Chlorophenylsulfonyl)-N'-propylurea
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to Chlorpropamide
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