Molecular Identity
Ciclopirox
6-cyclohexyl-1-hydroxy-4-methylpyridin-2-one
PubChem CID: 2749
Ciclopirox is a cyclic hydroxamic acid that is 1-hydroxypyridin-2(1H)-one in which the hydrogens at positions 4 and 6 are substituted by methyl and cyclohexyl groups, respectively. A broad spectrum antigfungal agent, it also exhibits antibacterial activity against many Gram-positive and Gram-negative bacteria, and has anti-inflammatory properties. It is used a a topical treatment of fungal skin and nail infections. It has a role as an antibacterial agent and an antiseborrheic. It is a cyclic hydroxamic acid, a pyridone and a hydroxypyridone antifungal drug.
2D Structure
Properties
C12H17NO2
Molecular Formula
207.27
Molecular Weight
g/mol
207.1259
Exact Mass
Da
2
XLogP
Drug-like (Lipinski: < 5)
40.5
TPSA
Good oral absorption (< 140 A²)
1
H-Bond Donors
2
H-Bond Acceptors
325
Complexity
SMILES
Canonical SMILES
SMILES: CC1=CC(=O)N(C(=C1)C2CCCCC2)OIsomeric SMILES
SMILES: CC1=CC(=O)N(C(=C1)C2CCCCC2)OSynonyms(20)
CICLOPIROX29342-05-0LoproxPenlacCiclopiroxumHOE 296b2(1H)-Pyridinone, 6-cyclohexyl-1-hydroxy-4-methyl-cyclopiroxHOE-296b6-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridinone6-cyclohexyl-1-hydroxy-4-methylpyridin-2-oneCiclodanCNL819W019ZDRJ2(1H)-Pyridone, 6-cyclohexyl-1-hydroxy-4-methyl-
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to Ciclopirox
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