Copanlisib
2-amino-N-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydro-1H-imidazo[1,2-c]quinazolin-5-ylidene]pyrimidine-5-carboxamide
Molecular Identity
Copanlisib
2-amino-N-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydro-1H-imidazo[1,2-c]quinazolin-5-ylidene]pyrimidine-5-carboxamide
PubChem CID: 135565596
Copanlisib is an imidazoquinazoline that is 2,3-dihydroimidazo[1,2-c]quinazoline substituted by (2-aminopyrimidine-5-carbonyl)amino, methoxy, and 3-(morpholin-4-yl)propoxy groups at positions 5, 7 and 8, respectively. It is a intravenous pan-class I PI3K inhibitor used for the treatment of relapsed follicular lymphoma in patients who have received at least 2 prior systemic therapies. It has a role as an antineoplastic agent, an EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor and an apoptosis inducer. It is a secondary carboxamide, an aromatic ether, an aminopyrimidine, a member of morpholines, a diether, an imidazoquinazoline, a pyrimidinecarboxamide and a tertiary amino compound.
2D Structure
Properties
C23H28N8O4
Molecular Formula
480.50
Molecular Weight
g/mol
480.2234
Exact Mass
Da
0.3
XLogP
Drug-like (Lipinski: < 5)
140
TPSA
May have limited oral absorption
2
H-Bond Donors
9
H-Bond Acceptors
974
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
Copanlisib1032568-63-0BAY 80-6946BAY-80-6946BAY80-6946BAY 80-6946 (Copanlisib)Aliqopa2-amino-N-(7-methoxy-8-(3-morpholinopropoxy)-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)pyrimidine-5-carboxamide2-Amino-N-[2,3-dihydro-7-methoxy-8-[3-(4-morpholinyl)propoxy]imidazo[1,2-c]quinazolin-5-yl]-5-pyrimidinecarboxamideMFCD18633201WI6V529FZ9Copanlisib (BAY 80-6946)C23H28N8O42-amino-N-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydro-1H-imidazo[1,2-c]quinazolin-5-ylidene]pyrimidine-5-carboxamide2-amino-N-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl]pyrimidine-5-carboxamide
Data from PubChem (NCBI)
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