Molecular Identity
Dapsone
4-(4-aminophenyl)sulfonylaniline
PubChem CID: 2955
Dapsone is a sulfone that is diphenylsulfone in which the hydrogen atom at the 4 position of each of the phenyl groups is substituted by an amino group. It is active against a wide range of bacteria, but is mainly employed for its actions against Mycobacterium leprae, being used as part of multidrug regimens in the treatment of all forms of leprosy. It has a role as an antiinfective agent, an anti-inflammatory drug, a leprostatic drug and an antimalarial. It is a sulfone and a substituted aniline. It is functionally related to a diphenyl sulfone.
2D Structure
Properties
C12H12N2O2S
Molecular Formula
248.30
Molecular Weight
g/mol
248.0619
Exact Mass
Da
1
XLogP
Drug-like (Lipinski: < 5)
94.6
TPSA
Good oral absorption (< 140 A²)
2
H-Bond Donors
4
H-Bond Acceptors
306
Complexity
SMILES
Canonical SMILES
SMILES: C1=CC(=CC=C1N)S(=O)(=O)C2=CC=C(C=C2)NIsomeric SMILES
SMILES: C1=CC(=CC=C1N)S(=O)(=O)C2=CC=C(C=C2)NSynonyms(20)
dapsone80-08-04,4'-SulfonyldianilineDiaphenylsulfone4,4'-Diaminodiphenyl sulfoneDapson4,4'-DiaminodiphenylsulfoneDADPSDiphenasoneNovophoneDisuloneSulfonaAvlosulfoneCroysulfoneDiaphenylsulfon
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to Dapsone
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