Desloratadine
13-chloro-2-piperidin-4-ylidene-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaene
Molecular Identity
Desloratadine
13-chloro-2-piperidin-4-ylidene-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaene
PubChem CID: 124087
Desloratadine is loratadine in which the ethoxycarbonyl group attached to the piperidine ring is replaced by hydrogen. The major metabolite of loratidine, desloratadine is an antihistamine which is used for the symptomatic relief of allergic conditions including rhinitis and chronic urticaria. It does not readily enter the central nervous system, so does not cause drowsiness. It has a role as a H1-receptor antagonist, a cholinergic antagonist, a drug metabolite and an anti-allergic agent.
2D Structure
Properties
C19H19ClN2
Molecular Formula
310.80
Molecular Weight
g/mol
310.1237
Exact Mass
Da
4.5
XLogP
Drug-like (Lipinski: < 5)
24.9
TPSA
Good oral absorption (< 140 A²)
1
H-Bond Donors
2
H-Bond Acceptors
425
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
Desloratadine100643-71-8ClarinexDescarboethoxyloratadineDesloratidineAeriusNeoclaritynAzomyrSch-34117DenosinAllexOpulisSch 341178-Chloro-11-piperidin-4-ylidene-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridineDesloratadine Actavis
Data from PubChem (NCBI)
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