Molecular Identity
Encainide
4-methoxy-N-[2-[2-(1-methylpiperidin-2-yl)ethyl]phenyl]benzamide
PubChem CID: 48041
Encainide is 4-Methoxy-N-phenylbenzamide in which the hydrogen at the 2 position of the phenyl group is substituted by a 2-(1-methylpiperidin-2-yl)ethyl group. A class Ic antiarrhythmic, the hydrochloride was used for the treatment of severe or life-threatening ventricular arrhythmias, but it was associated with increased death rates in patients who had asymptomatic heart rhythm abnormalities after a recent heart attack and was withdrawn from the market. It has a role as an anti-arrhythmia drug and a sodium channel blocker. It is a member of benzamides and a member of piperidines.
2D Structure
Properties
C22H28N2O2
Molecular Formula
352.50
Molecular Weight
g/mol
352.2151
Exact Mass
Da
4.3
XLogP
Drug-like (Lipinski: < 5)
41.6
TPSA
Good oral absorption (< 140 A²)
1
H-Bond Donors
3
H-Bond Acceptors
434
Complexity
SMILES
Canonical SMILES
SMILES: CN1CCCCC1CCC2=CC=CC=C2NC(=O)C3=CC=C(C=C3)OCIsomeric SMILES
SMILES: CN1CCCCC1CCC2=CC=CC=C2NC(=O)C3=CC=C(C=C3)OCSynonyms(20)
Encainide66778-36-7EncainidaEncainidum4-Methoxy-N-(2-(2-(1-methylpiperidin-2-yl)ethyl)phenyl)benzamideMJ 90674-methoxy-N-{2-[2-(1-methylpiperidin-2-yl)ethyl]phenyl}benzamideSY3J0147NB(+-)-4-Methoxy-N-(2-(2-(1-methyl-2-piperidinyl)ethyl)phenyl)benzamide4-methoxy-N-[2-[2-(1-methylpiperidin-2-yl)ethyl]phenyl]benzamideBENZAMIDE, 4-METHOXY-N-(2-(2-(1-METHYL-2-PIPERIDINYL)ETHYL)PHENYL)-, (+-)-CHEBI:4788DTXSID0022983(+-)-2'-[2-(1-methyl-2-piperidyl)ethyl]-p-anisanilide4-methoxy-2'-[2-(1-methyl-2-piperidyl)ethyl]benzanilide
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to Encainide
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