Molecular Identity
Floxuridine
5-fluoro-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
PubChem CID: 5790
Floxuridine is a pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract. It has a role as a radiosensitizing agent, an antimetabolite, an antineoplastic agent and an antiviral drug. It is a pyrimidine 2'-deoxyribonucleoside, an organofluorine compound and a nucleoside analogue.
2D Structure
Properties
C9H11FN2O5
Molecular Formula
246.19
Molecular Weight
g/mol
246.0652
Exact Mass
Da
-1.2
XLogP
Drug-like (Lipinski: < 5)
99.1
TPSA
Good oral absorption (< 140 A²)
3
H-Bond Donors
6
H-Bond Acceptors
386
Complexity
SMILES
Canonical SMILES
SMILES: C1C(C(OC1N2C=C(C(=O)NC2=O)F)CO)OIsomeric SMILES
SMILES: C1[C@@H]([C@H](O[C@H]1N2C=C(C(=O)NC2=O)F)CO)OSynonyms(20)
floxuridine50-91-95-Fluorodeoxyuridine2'-Deoxy-5-fluorouridineFluorodeoxyuridineFUDRFluoruridine deoxyribose5FdUFdUrdFloxuridinDeoxyfluorouridineFDUR5-Fluoro-2-desoxyuridineFloxuridinumFloxiridina
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to Floxuridine
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