Fluticasone furoate
[(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-17-(fluoromethylsulfanylcarbonyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] furan-2-carboxylate
Molecular Identity
Fluticasone furoate
[(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-17-(fluoromethylsulfanylcarbonyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] furan-2-carboxylate
PubChem CID: 9854489
Fluticasone furoate is a trifluorinated corticosteroid that consists of 6alpha,9-difluoro-11beta,17alpha-dihydroxy-17beta-{[(fluoromethyl)sulfanyl]carbonyl}-16-methyl-3-oxoandrosta-1,4-diene bearing a 2-furoyl substituent at position 17. Used in combination with vilanterol trifenate for treatment of bronchospasm associated with chronic obstructive pulmonary disease. It has a role as an anti-asthmatic drug, a prodrug and an anti-allergic agent. It is an 11beta-hydroxy steroid, a steroid ester, a fluorinated steroid, a 2-furoate ester, a corticosteroid, a thioester and a 3-oxo-Delta(1),Delta(4)-steroid. It is functionally related to a fluticasone. It derives from a hydride of an androstane.
2D Structure
Properties
C27H29F3O6S
Molecular Formula
538.60
Molecular Weight
g/mol
538.1637
Exact Mass
Da
4.8
XLogP
Drug-like (Lipinski: < 5)
119
TPSA
Good oral absorption (< 140 A²)
1
H-Bond Donors
10
H-Bond Acceptors
1080
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
Fluticasone furoate397864-44-7VeramystAllermistAvamysFuramistArnuity ElliptaEnnhaleFlonase SensimistGSK 685 698furoate de fluticasonefuroato de fluticasonafluticasonum furoasGW685698XGSK 685698
Data from PubChem (NCBI)
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