Givinostat
[6-(diethylaminomethyl)naphthalen-2-yl]methyl N-[4-(hydroxycarbamoyl)phenyl]carbamate
Molecular Identity
Givinostat
[6-(diethylaminomethyl)naphthalen-2-yl]methyl N-[4-(hydroxycarbamoyl)phenyl]carbamate
PubChem CID: 9804992
Givinostat is a member of the class of naphthalenes that is naphthalene substituted by ({[4-(hydroxycarbamoyl)phenyl]carbamoyl}oxy)methyl and (diethylamino)methyl groups at positions 2 and 6, respectively. It is a histone deacetylase inhibitor indicated for individuals diagnosed with Duchenne muscular dystrophy. It has a role as an antineoplastic agent, an angiogenesis inhibitor, an EC 3.5.1.98 (histone deacetylase) inhibitor, an anti-inflammatory agent and an apoptosis inducer. It is a member of benzenes, a carbamate ester, a hydroxamic acid, a member of naphthalenes and a tertiary amino compound. It is a conjugate base of a givinostat(1+).
2D Structure
Properties
C24H27N3O4
Molecular Formula
421.50
Molecular Weight
g/mol
421.2002
Exact Mass
Da
3.6
XLogP
Drug-like (Lipinski: < 5)
90.9
TPSA
Good oral absorption (< 140 A²)
3
H-Bond Donors
5
H-Bond Acceptors
575
Complexity
SMILES
Canonical SMILES
SMILES: CCN(CC)CC1=CC2=C(C=C1)C=C(C=C2)COC(=O)NC3=CC=C(C=C3)C(=O)NOIsomeric SMILES
SMILES: CCN(CC)CC1=CC2=C(C=C1)C=C(C=C2)COC(=O)NC3=CC=C(C=C3)C(=O)NOSynonyms(20)
Givinostat497833-27-9ITF-2357Gavinostat[6-(diethylaminomethyl)naphthalen-2-yl]methyl N-[4-(hydroxycarbamoyl)phenyl]carbamate5P60F84FBHDUVYZATDTXSID70198049givinostatum(6-(diethylaminomethyl)naphthalen-2-yl)methyl N-(4-(hydroxycarbamoyl)phenyl)carbamateRefChem:143259DTXCID50120540ITF2357Givinostat [INN](6-((diethylamino)methyl)naphthalen-2-yl)methyl (4-(hydroxycarbamoyl)phenyl)carbamate
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to Givinostat
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