Molecular Identity
glyburide
5-chloro-N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-2-methoxybenzamide
PubChem CID: 3488
Glyburide is an N-sulfonylurea that is acetohexamide in which the acetyl group is replaced by a 2-(5-chloro-2-methoxybenzamido)ethyl group. It has a role as an EC 3.6.3.49 (channel-conductance-controlling ATPase) inhibitor, a hypoglycemic agent, an anti-arrhythmia drug and an EC 2.7.1.33 (pantothenate kinase) inhibitor. It is a N-sulfonylurea and a member of monochlorobenzenes.
2D Structure
Properties
C23H28ClN3O5S
Molecular Formula
494.00
Molecular Weight
g/mol
493.1438
Exact Mass
Da
4.8
XLogP
Drug-like (Lipinski: < 5)
122
TPSA
Good oral absorption (< 140 A²)
3
H-Bond Donors
5
H-Bond Acceptors
746
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
glyburideGlibenclamide10238-21-8GlynaseEugluconSemi-daonilLibanilGlibenclamidaGlibenclamidumCalabrenLederglibHB 419Glyburide (micronized)1-(p-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfonyl)-3-cyclohexylureaSX6K58TVWC
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to glyburide
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