Lomitapide
N-(2,2,2-trifluoroethyl)-9-[4-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]piperidin-1-yl]butyl]fluorene-9-carboxamide
Molecular Identity
Lomitapide
N-(2,2,2-trifluoroethyl)-9-[4-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]piperidin-1-yl]butyl]fluorene-9-carboxamide
PubChem CID: 9853053
Lomitapide is a member of the class of benzamides obtained by formal condensation of the carboxy group of 4'-(trifluoromethyl)biphenyl-2-carboxylic acid with the primary amino group of 9-[4-(4-aminopiperidin-1-yl)butyl]-N-(2,2,2-trifluoroethyl)-9H-fluorene-9-carboxamide. Used (as its mesylate salt) as a complement to a low-fat diet and other lipid-lowering treatments in patients with homozygous familial hypercholesterolemia. It has a role as an anticholesteremic drug and a MTP inhibitor. It is a member of benzamides, a member of fluorenes, a member of piperidines and a member of (trifluoromethyl)benzenes. It is a conjugate base of a lomitapide(1+).
2D Structure
Properties
C39H37F6N3O2
Molecular Formula
693.70
Molecular Weight
g/mol
693.2790
Exact Mass
Da
8.6
XLogP
Above Lipinski threshold
61.4
TPSA
Good oral absorption (< 140 A²)
2
H-Bond Donors
9
H-Bond Acceptors
1110
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
Lomitapide182431-12-5AEGR-733BMS-201038LojuxtaBMS 201038AEGR733lomitapidaBMS201038lomitapidumBMS-201038-0182KUB0583F9H-Fluorene-9-carboxamide, N-(2,2,2-trifluoroethyl)-9-[4-[4-[[[4'-(trifluoromethyl)[1,1'-biphenyl]-2-yl]carbonyl]amino]-1-piperidinyl]butyl]-CHEBI:72297DTXSID50171294
Data from PubChem (NCBI)
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Trials and conditions connected to Lomitapide
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