Luteolin
2-(3,4-dihydroxyphenyl)-5,7-dihydroxychromen-4-one
Molecular Identity
Luteolin
2-(3,4-dihydroxyphenyl)-5,7-dihydroxychromen-4-one
PubChem CID: 5280445
Luteolin is a tetrahydroxyflavone in which the four hydroxy groups are located at positions 3', 4', 5 and 7. It is thought to play an important role in the human body as an antioxidant, a free radical scavenger, an anti-inflammatory agent and an immune system modulator as well as being active against several cancers. It has a role as an antineoplastic agent, an angiogenesis inhibitor, a radical scavenger, an immunomodulator, a vascular endothelial growth factor receptor antagonist, an anti-inflammatory agent, an apoptosis inducer, an EC 2.3.1.85 (fatty acid synthase) inhibitor, a nephroprotective agent, a plant metabolite and a c-Jun N-terminal kinase inhibitor. It is a 3'-hydroxyflavonoid and a tetrahydroxyflavone. It is a conjugate acid of a luteolin-7-olate.
2D Structure
Properties
C15H10O6
Molecular Formula
286.24
Molecular Weight
g/mol
286.0477
Exact Mass
Da
1.4
XLogP
Drug-like (Lipinski: < 5)
107
TPSA
Good oral absorption (< 140 A²)
4
H-Bond Donors
6
H-Bond Acceptors
447
Complexity
SMILES
Canonical SMILES
SMILES: C1=CC(=C(C=C1C2=CC(=O)C3=C(C=C(C=C3O2)O)O)O)OIsomeric SMILES
SMILES: C1=CC(=C(C=C1C2=CC(=O)C3=C(C=C(C=C3O2)O)O)O)OSynonyms(20)
luteolin491-70-33',4',5,7-TetrahydroxyflavoneDigitoflavoneLuteolol2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-oneFlacitranLuteolineSalifazideYama kariyasuWeld Lake5,7,3',4'-TetrahydroxyflavoneCyanidenon-14702-(3,4-dihydroxyphenyl)-5,7-dihydroxychromen-4-one2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4-benzopyrone
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to Luteolin
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