Molecular Identity
Metolazone
7-chloro-2-methyl-3-(2-methylphenyl)-4-oxo-1,2-dihydroquinazoline-6-sulfonamide
PubChem CID: 4170
Metolazone is a quinazoline that consists of 1,2,3,4-tetrahydroquinazolin-4-one bearing additional methyl, 2-tolyl, sulfamyl and chloro substituents at positions 2, 3, 6 and 7 respectively. A quinazoline diuretic, with properties similar to thiazide diuretics. It has a role as a diuretic, an antihypertensive agent and an ion transport inhibitor. It is a sulfonamide, an organochlorine compound and a member of quinazolines.
2D Structure
Properties
C16H16ClN3O3S
Molecular Formula
365.80
Molecular Weight
g/mol
365.0601
Exact Mass
Da
4.1
XLogP
Drug-like (Lipinski: < 5)
101
TPSA
Good oral absorption (< 140 A²)
2
H-Bond Donors
5
H-Bond Acceptors
594
Complexity
SMILES
Canonical SMILES
SMILES: CC1NC2=CC(=C(C=C2C(=O)N1C3=CC=CC=C3C)S(=O)(=O)N)ClIsomeric SMILES
SMILES: CC1NC2=CC(=C(C=C2C(=O)N1C3=CC=CC=C3C)S(=O)(=O)N)ClSynonyms(20)
metolazone17560-51-9ZaroxolynDiuloMykroxOldrenMetenixMetalozoneMetolazonaMetolazonummetozaloneNormelanXuretSR 720-227-Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to Metolazone
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