Midostaurin
N-[(2S,3R,4R,6R)-3-methoxy-2-methyl-16-oxo-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-4-yl]-N-methylbenzamide
Molecular Identity
Midostaurin
N-[(2S,3R,4R,6R)-3-methoxy-2-methyl-16-oxo-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-4-yl]-N-methylbenzamide
PubChem CID: 9829523
Midostaurin is an organic heterooctacyclic compound that is the N-benzoyl derivative of staurosporine. It has a role as an antineoplastic agent and an EC 2.7.11.13 (protein kinase C) inhibitor. It is a member of benzamides, an organic heterooctacyclic compound, an indolocarbazole and a gamma-lactam. It is functionally related to a staurosporine.
2D Structure
Properties
C35H30N4O4
Molecular Formula
570.60
Molecular Weight
g/mol
570.2267
Exact Mass
Da
4.8
XLogP
Drug-like (Lipinski: < 5)
77.7
TPSA
Good oral absorption (< 140 A²)
1
H-Bond Donors
4
H-Bond Acceptors
1140
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
Midostaurin120685-11-2PKC412Cgp 41251PKC 412PKC-412RYDAPTCGP-41251BenzoylstaurosporineN-BenzoylstaurosporinemidostaurinamidostaurineCgp 41 251ID912S5VONNVP-PKC412
Data from PubChem (NCBI)
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Trials and conditions connected to Midostaurin
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