Mitoguazone
2-[(E)-[(1E)-1-(diaminomethylidenehydrazinylidene)propan-2-ylidene]amino]guanidine
Molecular Identity
Mitoguazone
2-[(E)-[(1E)-1-(diaminomethylidenehydrazinylidene)propan-2-ylidene]amino]guanidine
PubChem CID: 5351154
Mitoguazone is a hydrazone obtained by formal condensation of the two carbonyl groups of methylglyoxal with the primary amino groups of two molecules of aminoguanidine. It has a role as an antineoplastic agent, an apoptosis inducer and an EC 4.1.1.50 (adenosylmethionine decarboxylase) inhibitor. It is a member of guanidines and a hydrazone. It is functionally related to a methylglyoxal and an aminoguanidine. It is a conjugate base of a mitoguazone(2+).
2D Structure
Properties
C5H12N8
Molecular Formula
184.20
Molecular Weight
g/mol
184.1185
Exact Mass
Da
-2.2
XLogP
Drug-like (Lipinski: < 5)
154
TPSA
May have limited oral absorption
4
H-Bond Donors
4
H-Bond Acceptors
264
Complexity
SMILES
Canonical SMILES
SMILES: CC(=NN=C(N)N)C=NN=C(N)NIsomeric SMILES
SMILES: C/C(=N\N=C(N)N)/C=N/N=C(N)NSynonyms(20)
MGBGMethyl-GagMitoguazonaMe-GAGMitoguazonumMethyl-GZyrkamineMethylglyoxal bis(amidinohydrazone)Methyl GAGMethylglyoxal bis(guanylhydrazone)CHEBI:43996NSC329461,1'-((Methylethanediylidene)dinitrilo)diguanidineMethylgagHydrazinecarboximidamide, 2,2'-(1-methyl-1,2-ethanediylidene)bis-
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to Mitoguazone
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