Nepafenac
2-(2-amino-3-benzoylphenyl)acetamide
Molecular Identity
Nepafenac
2-(2-amino-3-benzoylphenyl)acetamide
PubChem CID: 151075
Nepafenac is a monocarboxylic acid amide that is amfenac in which the carboxylic acid group has been converted into the corresponding carboxamide. It is a prodrug for amfenac, used in eye drops to treat pain and inflammation following cataract surgery. It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, a prodrug, a cyclooxygenase 2 inhibitor and a cyclooxygenase 1 inhibitor.
2D Structure
Properties
C15H14N2O2
Molecular Formula
254.28
Molecular Weight
g/mol
254.1055
Exact Mass
Da
1.9
XLogP
Drug-like (Lipinski: < 5)
86.2
TPSA
Good oral absorption (< 140 A²)
2
H-Bond Donors
3
H-Bond Acceptors
337
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
Nepafenac78281-72-82-(2-Amino-3-benzoylphenyl)acetamideNevanac2-Amino-3-benzoylbenzeneacetamideAHR-9434IlevroAL-6515nepafenacoAL 6515nepafenacum0J9L7J6V8CDTXSID0048638CHEBI:75922DTXCID7028564
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to Nepafenac
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