Molecular Identity
Nortriptyline
N-methyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylidene)propan-1-amine
PubChem CID: 4543
Nortriptyline is an organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(methylamino)propylidene group at position 5. It is an active metabolite of amitriptyline. It has a role as an antidepressant, an analgesic, an antineoplastic agent, an adrenergic uptake inhibitor, a drug metabolite and an apoptosis inducer. It is a secondary amine and an organic tricyclic compound. It is functionally related to an amitriptyline. It derives from a hydride of a dibenzo[a,d][7]annulene.
2D Structure
Properties
C19H21N
Molecular Formula
263.40
Molecular Weight
g/mol
263.1674
Exact Mass
Da
4.5
XLogP
Drug-like (Lipinski: < 5)
12
TPSA
Good oral absorption (< 140 A²)
1
H-Bond Donors
1
H-Bond Acceptors
307
Complexity
SMILES
Canonical SMILES
SMILES: CNCCC=C1C2=CC=CC=C2CCC3=CC=CC=C31Isomeric SMILES
SMILES: CNCCC=C1C2=CC=CC=C2CCC3=CC=CC=C31Synonyms(20)
nortriptyline72-69-5NoramitriptylineDesitriptilinaAtebenAvantylLumbeckDesmethylamitriptylineNoritrenSensavalDemethylamitriptylineSesavalDemethylamitryptylineNortryptilineNortryptyline
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to Nortriptyline
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