Molecular Identity
Olsalazine
5-[(3-carboxy-4-hydroxyphenyl)diazenyl]-2-hydroxybenzoic acid
PubChem CID: 22419
Olsalazine is an azobenzene that consists of two molecules of 4-aminosalicylic acid joined by an azo linkage. A prodrug for mesalazine, an anti-inflammatory drug, it is used (as the disodium salt) in the treatment of inflammatory bowel disease. It has a role as a non-steroidal anti-inflammatory drug and a prodrug. It is a member of azobenzenes and a dicarboxylic acid. It is functionally related to a salicylic acid. It is a conjugate acid of an olsalazine(2-).
2D Structure
Properties
C14H10N2O6
Molecular Formula
302.24
Molecular Weight
g/mol
302.0539
Exact Mass
Da
3.1
XLogP
Drug-like (Lipinski: < 5)
140
TPSA
May have limited oral absorption
4
H-Bond Donors
8
H-Bond Acceptors
415
Complexity
SMILES
Canonical SMILES
SMILES: C1=CC(=C(C=C1N=NC2=CC(=C(C=C2)O)C(=O)O)C(=O)O)OIsomeric SMILES
SMILES: C1=CC(=C(C=C1N=NC2=CC(=C(C=C2)O)C(=O)O)C(=O)O)OSynonyms(20)
Olsalazine15722-48-2OlsalazinaOlsalazinumDipentumRasal5,5'-Azobis(salicylic acid)3,3'-Azobis(6-hydroxybenzoic acid)Salicylic acid, 5,5'-azodi-C. i. mordant yellow 5OLSALAZINE [INN]Azodisal5,5'-azodisalicylic acidULS5I8J03O5,5'-(diazene-1,2-diyl)bis(2-hydroxybenzoic acid)
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to Olsalazine
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