Molecular Identity
Pilsicainide
N-(2,6-dimethylphenyl)-2-(1,2,3,5,6,7-hexahydropyrrolizin-8-yl)acetamide
PubChem CID: 4820
Pilsicainide is a secondary carboxamide resulting from the formal condensation of the amino group of 2,6-dimethylaniline with the carboxy group of (tetrahydro-1H-pyrrolizin-7a(5H)-yl)acetic acid. It is a sodium channel blocker which is used as an antiarrhythmic drug for the management of atrial tachyarrhythmias in Japan. It has a role as an anti-arrhythmia drug and a sodium channel blocker. It is a secondary carboxamide and an organic heterobicyclic compound.
2D Structure
Properties
C17H24N2O
Molecular Formula
272.40
Molecular Weight
g/mol
272.1889
Exact Mass
Da
2.7
XLogP
Drug-like (Lipinski: < 5)
32.3
TPSA
Good oral absorption (< 140 A²)
1
H-Bond Donors
2
H-Bond Acceptors
348
Complexity
SMILES
Canonical SMILES
SMILES: CC1=C(C(=CC=C1)C)NC(=O)CC23CCCN2CCC3Isomeric SMILES
SMILES: CC1=C(C(=CC=C1)C)NC(=O)CC23CCCN2CCC3Synonyms(20)
Pilsicainide88069-67-4PilzicainidePilsicainidaPilsicainidumDTXSID1046639N-(2,6-Dimethylphenyl)-2-(hexahydro-1H-pyrrolizin-7a-yl)acetamideAV0X7V6CSETetrahydro-1H-pyrrolizine-7a(5H)-aceto-2',6'-xylidideDTXCID9026639CHEBI:135127RefChem:174259Pilsicainide [INN]N-(2,6-dimethylphenyl)-2-(1,2,3,5,6,7-hexahydropyrrolizin-8-yl)acetamideN-(2,6-Dimethylphenyl)-2-(tetrahydro-1H-pyrrolizin-7a(5H)-yl)acetamide
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to Pilsicainide
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