Pitavastatin
(E,3R,5S)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoic acid
Molecular Identity
Pitavastatin
(E,3R,5S)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoic acid
PubChem CID: 5282452
Pitavastatin is a dihydroxy monocarboxylic acid that is (6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]hept-6-enoic acid in which the two hydroxy groups are located at positions 3 and 5 (the 3R,5S-stereoisomer). Used as its calcium salt for treatment of hypercholesterolemia (elevated levels of cholesterol in the blood) on patients unable to sufficiently lower their cholesterol levels by diet and exercise. It has a role as an antioxidant. It is a member of quinolines, a dihydroxy monocarboxylic acid, a member of cyclopropanes, a member of monofluorobenzenes and a statin (synthetic). It is a conjugate acid of a pitavastatin(1-).
2D Structure
Properties
C25H24FNO4
Molecular Formula
421.50
Molecular Weight
g/mol
421.1689
Exact Mass
Da
3.5
XLogP
Drug-like (Lipinski: < 5)
90.7
TPSA
Good oral absorption (< 140 A²)
3
H-Bond Donors
6
H-Bond Acceptors
631
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
Pitavastatin147511-69-1ItavastatinpitavastatineNK 104pitavastatinumPitavastatina(3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoic acidNIKITA6-Heptenoic acid, 7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-, (3R,5S,6E)-M5681Q5F9PNK-104(3R,5S,6E)-7-(2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoic acidNSC-760423K-924 component Pivastatin
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to Pitavastatin
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