Senicapoc
2,2-bis(4-fluorophenyl)-2-phenylacetamide
Molecular Identity
Senicapoc
2,2-bis(4-fluorophenyl)-2-phenylacetamide
PubChem CID: 216327
Senicapoc is an orally bioavailable inhibitor of the calcium-activated potassium channel KCa3.1 (Gardos channel; KCNN4; IK-1; SK4), with potential anti-inflammatory and immunomodulatory activities. Upon oral administration, senicapoc targets, binds to and inhibits KCa3.1.
2D Structure
Properties
C20H15F2NO
Molecular Formula
323.30
Molecular Weight
g/mol
323.1122
Exact Mass
Da
4.1
XLogP
Drug-like (Lipinski: < 5)
43.1
TPSA
Good oral absorption (< 140 A²)
1
H-Bond Donors
3
H-Bond Acceptors
397
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
Senicapoc289656-45-72,2-bis(4-fluorophenyl)-2-phenylacetamideBis(4-fluorophenyl)phenylacetamideTS6G201A6QPF-05416266DTXSID60276906ICA17043senicapocumRefChem:182393DTXCID70228072ICA-17043MFCD09027349C20H15F2NOSenicapoc (USAN)
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to Senicapoc
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