Suzetrigine
4-[[(2R,3S,4S,5R)-3-(3,4-difluoro-2-methoxyphenyl)-4,5-dimethyl-5-(trifluoromethyl)oxolane-2-carbonyl]amino]pyridine-2-carboxamide
Molecular Identity
Suzetrigine
4-[[(2R,3S,4S,5R)-3-(3,4-difluoro-2-methoxyphenyl)-4,5-dimethyl-5-(trifluoromethyl)oxolane-2-carbonyl]amino]pyridine-2-carboxamide
PubChem CID: 156445116
Suzetrigine is a member of the class of oxolanes that is oxolane substituted by 4-aminoacyl-pyridine-2-carboxamide, 3,4-difluoro-2-methoxyphenyl, methyl, and trifluoromethyl groups at positions 2, 3, 4, 5, and 5, respectively (the 2R,3S,4S,5R-stereoisomer). It is a selective blocker of the NaV 1.8 voltage-gated sodium channel and has been approved for the treatment of moderate to severe acute pain in adults. It has a role as a non-narcotic analgesic and a voltage-gated sodium channel blocker. It is a primary carboxamide, a secondary carboxamide, a monomethoxybenzene, a pyridinecarboxamide, a member of oxolanes and a difluorobenzene.
2D Structure
Properties
C21H20F5N3O4
Molecular Formula
473.40
Molecular Weight
g/mol
473.1374
Exact Mass
Da
3
XLogP
Drug-like (Lipinski: < 5)
104
TPSA
Good oral absorption (< 140 A²)
2
H-Bond Donors
10
H-Bond Acceptors
741
Complexity
SMILES
Canonical SMILES
SMILES: CC1C(C(OC1(C)C(F)(F)F)C(=O)NC2=CC(=NC=C2)C(=O)N)C3=C(C(=C(C=C3)F)F)OCIsomeric SMILES
SMILES: C[C@H]1[C@H]([C@@H](O[C@@]1(C)C(F)(F)F)C(=O)NC2=CC(=NC=C2)C(=O)N)C3=C(C(=C(C=C3)F)F)OCSynonyms(20)
Suzetrigine2649467-58-1VX-548JOURNAVXVXC-548VRT-1737548LOG73M21H54-[[(2R,3S,4S,5R)-3-(3,4-difluoro-2-methoxyphenyl)-4,5-dimethyl-5-(trifluoromethyl)oxolane-2-carbonyl]amino]pyridine-2-carboxamide4-(((2R,3S,4S,5R)-3-(3,4-difluoro-2-methoxyphenyl)-4,5-dimethyl-5-(trifluoromethyl)oxolane-2-carbonyl)amino)pyridine-2-carboxamideRefChem:1099300SuzetriginaVX5484-[[[(2R,3S,4S,5R)-3-(3,4-Difluoro-2-methoxyphenyl)tetrahydro-4,5-dimethyl-5-(trifluoromethyl)-2-furanyl]carbonyl]amino]-2-pyridinecarboxamide4-((2R,3S,4S,5R)-3-(3,4-Difluoro-2-Methoxyphenyl)-4,5-Dimethyl-5-(Trifluoromethyl)Tetrahydrofuran-2-Carboxamido)PicolinamideCompound 7 [WO2021113627A1]
Data from PubChem (NCBI)
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Drug Network
Trials and conditions connected to Suzetrigine
Loading drug network...