Tedizolid Phosphate
[(5R)-3-[3-fluoro-4-[6-(2-methyltetrazol-5-yl)-3-pyridinyl]phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl dihydrogen phosphate
Molecular Identity
Tedizolid Phosphate
[(5R)-3-[3-fluoro-4-[6-(2-methyltetrazol-5-yl)-3-pyridinyl]phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl dihydrogen phosphate
PubChem CID: 11476460
Tedizolid phosphate is a phosphate monoester resulting from the formal condensation of equimolar amounts of phosphoric acid with the hydroxy group of tedizolid. It is a prodrug of tedizolid, used for the treatment of acute bacterial skin infections caused by certain susceptible bacteria, including Staphylococcus aureus (including methicillin-resistant strains (MRSA) and methicillin-susceptible strains), various Streptococcus species, and Enterococcus faecalis. It has a role as an antimicrobial agent, a protein synthesis inhibitor and a prodrug. It is a carbamate ester, a member of pyridines, a member of tetrazoles, an organofluorine compound, an oxazolidinone and a phosphate monoester.
2D Structure
Properties
C17H16FN6O6P
Molecular Formula
450.30
Molecular Weight
g/mol
450.0853
Exact Mass
Da
0.3
XLogP
Drug-like (Lipinski: < 5)
153
TPSA
May have limited oral absorption
2
H-Bond Donors
11
H-Bond Acceptors
702
Complexity
SMILES
Canonical SMILES
SMILES: CN1N=C(N=N1)C2=NC=C(C=C2)C3=C(C=C(C=C3)N4CC(OC4=O)COP(=O)(O)O)FIsomeric SMILES
SMILES: CN1N=C(N=N1)C2=NC=C(C=C2)C3=C(C=C(C=C3)N4C[C@@H](OC4=O)COP(=O)(O)O)FSynonyms(20)
Tedizolid phosphate856867-55-5Torezolid phosphateSivextroTR-701 FATR-701FATR-701-FAO7DRJ6R4DWCHEBI:83326DA7218DTXSID30234977[(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridin-3-yl]phenyl}-2-oxo-1,3-oxazolidin-5-yl]methyl dihydrogen phosphate{[(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-1,2,3,4-tetrazol-5-yl)pyridin-3-yl]phenyl}-2-oxo-1,3-oxazolidin-5-yl]methoxy}phosphonic acid(((5R)-3-(3-fluoro-4-(6-(2-methyl-2H-1,2,3,4-tetrazol-5-yl)pyridin-3-yl)phenyl)-2-oxo-1,3-oxazolidin-5-yl)methoxy)phosphonic acid((5R)-3-(3-fluoro-4-(6-(2-methyl-2H-tetrazol-5-yl)pyridin-3-yl)phenyl)-2-oxo-1,3-oxazolidin-5-yl)methyl dihydrogen phosphate
Data from PubChem (NCBI)
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Trials and conditions connected to Tedizolid Phosphate
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