Tivozanib
1-[2-chloro-4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-3-(5-methyl-1,2-oxazol-3-yl)urea
Molecular Identity
Tivozanib
1-[2-chloro-4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-3-(5-methyl-1,2-oxazol-3-yl)urea
PubChem CID: 9911830
Tivozanib is a member of the class of quinolines that is 6,7-dimethoxyquinoline substituted by a 3-chloro-4-{[(5-methyl-1,2-oxazol-3-yl)carbamoyl]amino}phenoxy group at position 4. It is a potent and selective inhibitor of VEGF receptor tyrosine kinases and was previously in clinical development for the treatment of metastatic renal cell carcinoma. It has a role as an antineoplastic agent, a vascular endothelial growth factor receptor antagonist and an apoptosis inducer. It is a member of phenylureas, a member of quinolines, an aromatic ether, a member of isoxazoles and a member of monochlorobenzenes.
2D Structure
Properties
C22H19ClN4O5
Molecular Formula
454.90
Molecular Weight
g/mol
454.1044
Exact Mass
Da
4
XLogP
Drug-like (Lipinski: < 5)
108
TPSA
Good oral absorption (< 140 A²)
2
H-Bond Donors
7
H-Bond Acceptors
631
Complexity
SMILES
Canonical SMILES
SMILES: CC1=CC(=NO1)NC(=O)NC2=C(C=C(C=C2)OC3=C4C=C(C(=CC4=NC=C3)OC)OC)ClIsomeric SMILES
SMILES: CC1=CC(=NO1)NC(=O)NC2=C(C=C(C=C2)OC3=C4C=C(C(=CC4=NC=C3)OC)OC)ClSynonyms(20)
Tivozanib475108-18-0AV-951KRN-951AV951KRN951KIL8951Kil-8951AV951 cpd172030934TDTXSID209638651-{2-chloro-4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-3-(5-methyl-1,2-oxazol-3-yl)ureaUrea, N-(2-chloro-4-((6,7-dimethoxy-4-quinolinyl)oxy)phenyl)-N'-(5-methyl-3-isoxazolyl)-tivozanibum1-(2-chloro-4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)-3-(5-methyl-1,2-oxazol-3-yl)urea
Data from PubChem (NCBI)
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