Molecular Identity
topotecan
(19S)-8-[(dimethylamino)methyl]-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione
PubChem CID: 60700
Topotecan is a pyranoindolizinoquinoline used as an antineoplastic agent. It is a derivative of camptothecin and works by binding to the topoisomerase I-DNA complex and preventing religation of these 328 single strand breaks. It has a role as an antineoplastic agent and an EC 5.99.1.2 (DNA topoisomerase) inhibitor.
2D Structure
Properties
C23H23N3O5
Molecular Formula
421.40
Molecular Weight
g/mol
421.1638
Exact Mass
Da
0.5
XLogP
Drug-like (Lipinski: < 5)
103
TPSA
Good oral absorption (< 140 A²)
2
H-Bond Donors
7
H-Bond Acceptors
867
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
topotecan123948-87-8HycamptamineTopotecan lactoneNogitecanHycamptinTopotecane(S)-TopotecanTopotecanumTopophore CTopoCEDSKF-104864-A9-Dimethylaminomethyl-10-hydroxycamptothecinNSC-641007SKF-104864
Data from PubChem (NCBI)
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Drug Network
Trials and conditions connected to topotecan
Loading drug network...