Receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. NELL2 is an endogenous ligand for ROS1. Upon endogenous stimulation by NELL2, ROS1 activates the intracellular signaling pathway and triggers epididymal epithelial differentiation and subsequent sperm maturation (By similarity). May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2. {ECO:0000250|UniProtKB:Q78DX7, ECO:0000269|PubMed:11094073, ECO:0000269|PubMed:16885344}.
Chromosome
6
Biotype
protein_coding
Diseases
25
Variants
50
Also Known As
25 disease associations found
| Disease | Score | Therapeutic Areas |
|---|---|---|
| non-small cell lung carcinoma | 0.71 | respiratory or thoracic diseasecancer or benign tumor |
| neoplasm | 0.60 | cancer or benign tumor |
| lung adenocarcinoma | 0.59 | cancer or benign tumorrespiratory or thoracic disease |
| cancer | 0.50 | cancer or benign tumor |
| lung carcinoma | 0.45 | respiratory or thoracic diseasecancer or benign tumor |
| melanoma | 0.40 | cancer or benign tumor |
| squamous cell lung carcinoma | 0.39 | respiratory or thoracic diseasecancer or benign tumor |
| cutaneous melanoma | 0.38 | integumentary system disordercancer or benign tumor |
| spitz nevus | 0.37 | integumentary system disordercancer or benign tumor |
| melanocytic neoplasm | 0.37 | cancer or benign tumor |
| lymphoid neoplasm | 0.37 | hematologic disordercancer or benign tumor |
| bile duct carcinoma | 0.37 | hepatobiliary disorderendocrine system disordergastrointestinal diseasecancer or benign tumor |
| Meningothelial Meningioma | 0.37 | nervous system disordercancer or benign tumor |
| Atypical Meningioma | 0.37 | nervous system disordercancer or benign tumor |
| ovarian endometrioid adenocarcinoma with squamous differentiation | 0.37 | reproductive system or breast diseasecancer or benign tumorendocrine system disorder |
4 drugs targeting this gene
EML4-ALK inhibitor
ALK tyrosine kinase receptor inhibitor
NT-3 growth factor receptor inhibitor
Neurotrophic tyrosine kinase receptor inhibitor
50 variants reported
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