Alzheimer's Disease Prevention Trial

National Institute on Aging (NIA)

Overview

This is a three-year study to determine if estrogens can prevent memory loss and Alzheimer's disease in women with a family history of Alzheimer's disease.

PREventing Postmenopausal memory loss and Alzheimer's with Replacement Estrogens (PREPARE) is a double-blind-placebo controlled trial to determine whether estrogen (or estrogen and progesterone) can delay the onset of memory loss or Alzheimer's Disease in elderly women with a family history of the disease.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Conditions

Alzheimer Disease Memory Disorders

Interventions

EstrogenDRUG

Estrogen and ProgesteroneDRUG

Eligibility

Sex: FEMALEMin age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy women 65 or older with a family history of memory problems not currently on estrogen. Exclusion Criteria: * Significant neurological impairment * Current estrogen use * History of breast cancer

Locations (22)

University of Alabama

Birmingham, Alabama, United States

Data from ClinicalTrials.gov

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